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Većina droga povećava količinu ovih neurotransmitera vršeći njihovo djelovanje i oni mogu pružiti osjećaj zadovoljstva, što je euforija.Kokain dapat menyebabkan gagal ginjal akut. Penderita hipertensi yang juga pengguna kokain dapat mengalami percepatan kerusakan ginjal jangka panjang, karena kokain dapat meningkatkan tekanan darah.Abstract